Does Diabetes Medication Cause Weight Loss?

Does Diabetes Medication Cause Weight Loss? 

What’s the best medication to lose weight with? There are several choices, including Metformin, Liraglutide, SGLT2 inhibitors, and Tirzepatide. Each one can cause weight loss depending on the person’s metabolism and body fat levels. But before you choose a treatment, ask your doctor about the side effects. A diabetes educator can help you find the right medication for your unique situation. 

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Many of us take metformin for diabetes, but do they cause weight loss? The answer depends on the type of diabetes and the person’s lifestyle. In some studies, metformin can cause weight loss. One study of men and women with prediabetes found that patients on metformin lost an average of 4.6 pounds in the first year. Other studies have shown similar results. But there’s still much to learn. 

While metformin is a common diabetes treatment, it can have potentially dangerous side effects. The FDA has issued the highest level of warning for metformin. Among these side effects is lactic acidosis, which causes an unsafe buildup of lactic acid in the blood. In some people, metformin can also cause a low blood sugar reaction. This side effect is treatable by taking 15 to 20 grams of glucose in the form of sugary drinks or hard candies. 


If you have diabetes and are taking diabetes medication, you may have heard about Liraglutide, a medication for type 2 diabetes. Liraglutide has been proven to reduce weight, improve cardiometabolic parameters, and delay the onset of type 2 diabetes. However, it’s not clear if the drug will cause weight loss or cause side effects. This article discusses what you need to know about Liraglutide and weight loss. 

The first study evaluated the effects of liraglutide on body weight and other metabolic parameters associated with cardiovascular disease. Researchers noted that liraglutide caused significant weight loss in people with type 2 diabetes and a history of hypertension. The study also measured the frequency of metabolic syndrome in participants. The results were positive for both treatments. Overall, it’s safe to assume that Liraglutide will reduce the risks of cardiovascular disease. 

SGLT2 inhibitors 

There are concerns regarding the potential interaction between SGLT2 inhibitors and diabetes medications, but the two are not mutually exclusive. Recent research has shown that both diabetes medications and SGLT2 inhibitors can reduce the risk of heart failure. A review from 2018 found that SGLT2 inhibitors reduced the risk of heart failure by 23 percent, regardless of diabetes history. Therefore, these medications are useful for both people with and without type 2 diabetes. 

Taking SGLT2 inhibitors may cause weight loss, but how much is the weight loss? This study shows that the weight loss from SGLT2 inhibitors was related to an increase in energy expenditure, a decrease in lean tissue mass, and mild osmotic diuresis. This results in an overall weight loss of about five kilograms, which is less than most people expect to lose. 


A new study has shown that patients taking insulin-like diabetes medications like tripeptide can lose weight. In the study, participants lost between 15% and 20 percent of their starting body weight over 72 weeks. The study involved over 2,500 people, with a baseline BMI of greater than 30. Participants were generally overweight or obese and many had diabetes or other conditions related to weight. They also had higher blood pressure, heart disease, and obstructive sleep apnea. 

In a recent study, researchers found that tirzepatide improved daily glucose profiles in type 2 diabetes patients. Specifically, the drug improved the TIR, or Time in Tighter Range, or the percent of time patients spend within the tight glucose range. This drug may be particularly useful for treating non-alcoholic fatty liver disease, as people with this disease are more likely to have the disorder. The study found that tirzepatide improved TIR significantly, compared to degludec alone. Interestingly, the treatment reduced the patient’s weight by 50 pounds.